|
KMID : 0378019720150050114
|
|
New Medical Journal
1972 Volume.15 No. 5 p.114 ~ p.117
|
|
|
Influence of Panax Ginseng upon ACTH-induced Change in Rat´s Adrenal Ascorbic Acid Content
|
|
|
|
|
Abstract
|
|
|
A study was planned to evaluate the influence of ginseng upon ACTH-induced change in rat´s
adrenal ascorbic acid content and to compare it with the influence of the same drug upon stress
induced change in adrenal ascorbic acid content.
One hundred twenty rats were equally divided into the saline control, the ginseng control, the saline-ACTH, and the ginseng-ACTH groups, according to the drugs they received. For 5 or 7 days the ginseng and the ginseng-ACTH groups received 0, 5 ml/100 gm body weight of ginseng alcohol extract soiution(4 mg of the extract in 1 ml of saline), while the saline and the saline-ACTH groups received the same amount of saline. In addition, animals belonging to the ginseng-ACTH and the saline-ACTH groups received, from the 5th day on, 0.01 unit of ACTH every day for 1 or 3 days.
One hour after the last ACTH administration, all animals were sacrificed under deep anesthesia and their adrenal ascorbic acid content was measured colorimetrically utilizing the reduction of 2, 6-dichlorophenol-indophenol sodium.
Following results were obtained:
1. In the saline-ACTH group, the adrenal ascorbic acid content decreased significanly 1 hr after the 1st ACTH administration. However, the decrease became less apparent upon repeated ACTH administration.
2. Decrease in adrenal ascorbic acid content, 1 hr after ACTH, of the ginseng group became more conspicuous upon repeated ACTH administration compared with the decrease after the 1st ACTH.
From the above results, which agree well with those obtained by inflicting stressful stimuli upon animals in the same situation, the ginseng was infered to facilitate response of animals to stress.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|